Facilities like hospitals and laboratories have unique building-performance needs. As we strive to create the next generation of sustainable, high performance buildings, balancing the specialized requirements of these facilities with the health, well-being and comfort of the occupants is critical. For a building design to be considered high performing, it must create a hyper productive space where occupants feel motivated and inspired to the point where they genuinely enjoy coming to work. Specific project case studies will be used to illustrate the challenges and provide context on the potential impact on the overall building performance. The seminar will also describe the process to identify, analyze and successfully mitigate these issues.